Blood coagulation analyzer using Elastic Motion Thrombelastography
ClotPro is a 6 channel viscoelastometry analyzer, designed for the rapid analysis of whole blood coagulation. It offers a unique combination of ease of use, flexibility, and throughput (6 channels for parallel testing). The system provides excellent correlation to conventional viscoelastometry analyzers.
ClotPro supports the management of acute blood coagulation disorders to facilitate the selection of the most appropriate therapy and stop bleeding.
The benefits of viscoelastic coagulation monitoring have been described in many fields of surgery and intensive care: Cardiac and vascular surgery, organ transplantation, trauma, obstetrics, orthopaedic surgery and intensive care.
ClotPro enables the detection and assessment of factor deficiencies, low fibrinogen, platelet contribution (to whole blood coagulation), heparin and DOAC effects, fibrinolysis and antifibrinolytic drugs.
Cutting edge coagulation assays
All reagent handling is eliminated with the ACTIVE-TIP technology. The pipette-tip contains test specific dry reagents. The reagents for each assay are present in dry form in a sponge in the pipette tip (left). During pipetting of the patient sample the reagent is automatically added to the blood (right) – simple and safe.
Liquid reagent handling for viscoelastometry requires pipetting of small reagent volumes, which is challenging in acute situations. The ClotPro® active-tip technology eliminates all reagent handling without requiring to run fixed 4 channel test panels. The diagnostic proficiency of viscoelastometry has been significantly enhanced by the development of three innovative assays designed to reflect advances in therapeutics.
9 different tests
ClotPro offers 9 tests, the established screening assays (EX-test, FIB-test, AP-test, IN-test, HI-test) and new assays for drug monitoring (RVV-test, ECA-test, TPA-test, NA-test). Small pack sizes (10 cartridges) further assists cost management and are ideal for smaller sites.
EX-test Rapid overview over the coagulation process
Ready to use system reagent for the assessment of the extrinsic coagulation pathway and its interaction with blood platelets in citrated blood on the ClotPro system. In EX-test CaCl2 recalcifies the sample and recombinant tissue factor activates coagulation. Hexadimethrine bromide is added to the reagent to antagonize any heparin that may be present in the sample.
FIB-test Functional detection of the fibrinogen level
Ready to use system reagent for examination of the fibrinogen level and fibrin polymerization in citrated blood on the ClotPro system. In FIB-test CaCl2 recalcifies the sample and recombinant tissue factor activates the extrinsic coagulation pathway. Platelets are inhibited by dual inhibition with cytochalasin D and a synthetic GP2b3a antagonist. Hexadimethrine bromide is added to the reagent to antagonize any heparin that may be present in the sample.
IN-test Assessment of heparin, sensitive to FVIII
Ready to use system reagent for the assessment of the intrinsic coagulation pathway and its interaction with blood platelets in citrated blood on the ClotPro system. CaCl2 recalcifies the sample and ellagic acid activates coagulation.
HI-test IN-test with heparin inhibition
Ready to use system reagent for heparin insensitive assessment of the intrinsic coagulation pathway and its interaction with blood platelets in citrated blood on the ClotPro system. HI-test neutralizes heparin in-vitro with heparinase. CaCl2 recalcifies the sample and ellagic acid activates coagulation.
AP-test Assessment of coagulation using fibrinolysis inhibition
Ready to use system reagent for the fibrinolysis-independent assessment of the extrinsic coagulation pathway and its interaction with blood platelets in citrated blood on the ClotPro system. In AP-test fibrinolysis is inhibited in-vitro using aprotinin, a potent direct antagonist of plasmin, the effector protease of fibrinolysis. CaCl2 recalcifies the sample and recombinant tissue factor activates coagulation. Hexadimethrine bromide is added to the reagent to antagonize heparin that may be present in the sample.
RVV-test Highly sensitive to direct oral anticoagulants (DOACs)
Ready to use system reagent for the detection of factor Xa (FXa) antagonists in citrated blood on the ClotPro system. CaCl2 recalcifies the sample and reagent derived from Russells viper venom (RVV) activates FX in the sample to FXa. This FXa triggers coagulation and clot formation.
ECA-test Highly sensitive to dabigatran
ECA-test is a ready to use system reagent for the detection of dabigatran in citrated blood for the ClotPro analyzer. Ecarin, a thrombin activator derived from the venom of the saw-scaled viper (Echis carinatus) activates prothrombin from the blood sample. Polybrene is added to the reagent to antagonize heparin that may be present in the sample.
TPA-test Assessment of coagulation with fibrinolysis activation
TPA-test is a ready to use system reagent for the assessment of the fibrinolytic response to tissue plasminogen activator (t-PA) in citrated blood for the ClotPro® analyzer. TPA-test in combination with the ClotPro analyzer is a semi-automated and semi-quantitative test.
NA-test Non activated test
Ready to use system reagent for the detection of non-activated coagulation in citrated blood on the ClotPro system. CaCl2 recalcifies the sample.